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The World Health Organization (WHO) estimates that AMR contributes to at least 700,000 deaths annually, a number projected to rise to 10 million by 2050 if not urgently addressed [3]

Trained immunity exerts long-lasting effects on cell function through epigenetic regulation and metabolic reprogramming ( Table 1 ) and shows bidirectional roles in immune regulation: disease-induced trained immunity can, in turn, exacerbate pathology, creating a self-reinforcing vicious cycle

However, when nerve damage has progressed too far, especially with long-term axonal loss, complete reversal is less likely

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Clinical trials show that this drug may help a lot with weight loss and glycemic control